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December 2021
Hui Zong, PhD
Dept of Microbiology, Immunology, and Cancer Biology, University of Virginia "the critical role of cell competition in gliomagenesis revealed by a mouse genetic mosaic system"
Find out more »Sarah K. England, PhD
Alan A. and Edith L. Wolff Professor of Medicine, Vice Chair of Research and Professor of Obstetrics and Gynecology, Interim Director, Center for Reproductive Health Sciences, Washington University School of Medicine. “Chronodisruption – A potential risk for adverse pregnancy outcomes.”
Find out more »Elizabeth Haswell, PhD
HHMI-Simons Faculty Scholar, Professor, Center for Engineering Mechanobiology, Dept. of Biology, Washington University. “Flattening the Curve: Mechanosensitive Ion Channels in Biology and Development”
Find out more »January 2022
Sarah Tishkoff, PhD
David and Lyn Silfen University Professor, Departments of Genetics and Biology, Perelman School of Medicine, School of Arts and Sciences, University of Pennsylvania. Genomic Evolution and Adaptation in Africa: Implications for Health and Disease.
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Jason L. Stein, PhD
Assistant Professor
Department of Genetics & Neuroscience Center
University of North Carolina-Chapel Hill
presents, “Genetic influences on human cortical development and structure” Hosted by: Dr. Joseph Dougherty
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***VIRTUAL SPECIAL SEMINAR***
Bohdan (Bo) Khomtchouk, PhD
Instructor
Department of Medicine
Section of Computational Biomedicine and Biomedical Data Science
Institute for Genomics and Systems Biology
University of Chicago
presents, "Cardioinformatics approaches for drug discovery"
Find out more »February 2022
Ye Zhang, PhD
Assistant Professor
Intellectual and Developmental Disabilities Research Center
Semel Institute for Neuroscience and Human Behavior
Department of Psychiatry and Biobehavioral Sciences
David Geffen School of Medicine
University of California Los Angeles
presents, "Astrocyte and oligodendrocyte biology in development and disease: lessons from humans and mice" Hosted by: Dr. Tristan Li
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Guoyan Zhao, PhD
Assistant Professor
Department of Neuroscience
Washington University School of Medicine
presents, "Striatal glia differentially contribute to Aβ pathology, tauopathy, and neurodegeneration" Hosted by: Dr. Joe Dougherty Seminar abstract: We performed the first single-nucleus transcriptome comparison of control, AD, and PD striata. We identified three astrocyte subpopulations and two microglia subpopulations conserved across different brain regions such as entorhinal cortex and prefrontal cortex, and between humans and mice. We reveal commonalities and differences between AD and PD glia and regional differences in their contributions toward amyloid pathology, tauopathy, and neurodegeneration.
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Introductory Seminar
Computational Biology & Bioinformatics Resource Portal
A New Collaborative WashU Portal
Zoom Link - https://wustl-hipaa.zoom.us/j/99906825464?pwd=b2hFcjlSblNNcnpHN0p4R0pIZ2VGdz09 A web-based portal connecting investigators to bioinformatic experts and resources. Looking for bioinformatic experts for analysis or collaboration? Pursuing computational tools or resources to support your research? Seeking educational resources or useful software? On the lookout for collaboration opportunities? Seminar: We will cover how investigators can use the portal to create collaboration requests or identify relevant educational or computational resources. We will also cover how contributors can identify collaborations that best leverage their expertise. Collaboration Requests: Investigators use a request page to provide details of their project and the type of assistance…
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Hugo Bellen, DVM, PhD
Professor
Departments of Molecular & Human Genetics and Neuroscience
Baylor College of Medicine
presents, "Tackling human gene function in model organisms" Hosted by: Dr. Tim Schedl Seminar abstract: It is estimated that there are more than 300 million patients worldwide with a rare genetic disease. Many of these patients remain undiagnosed for many years. By sequencing their genomes and those of their relatives, human geneticists can now discover genetic variations that are rare or ultra-rare. However, considering that there are many polymorphisms in the population, assessing which variant(s) is/are related to the observed…
Find out more »March 2022
Jacob Kitzman, PhD
Assistant Professor
Departments of Human Genetics and Computational Medicine & Bioinformatics
University of Michigan Medical School
presents, "Large-scale approaches to classify and understand genetic variants" hosted by: Dr. Barak Cohen
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McDonnell Genome Institute Seminar Series
Seminar 1 – New Technologies in GTAC@MGI
Zoom attendee link - https://wustl-hipaa.zoom.us/j/94667349011 One of the chief roles of MGI is to act as a bridge between researchers and rapidly evolving ‘omics technologies. Our facilities obtain these technologies and make them available to researchers both within and outside of WashU. In addition, we help to make biologic sense of the often-large datasets we produce. While we once specialized in sequencing, we have been significantly diversifying to include genome engineering, proteomics, metabolomics, sub-cellular imaging, machine learning, etc. To keep…
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Benjamin Garcia, PhD
Professor and Chair
Department of Biochemistry and Molecular Biophysics
Washington University School of Medicine
Hybrid: Connor Auditorium (FLTC), Zoom webinar attendee link: https://wustl-hipaa.zoom.us/j/94367220300 presents, "Quantitative proteomics for understanding epigenetic cancer mechanisms" hosted by: Dr. Susan Dutcher Seminar abstract: Histones are small proteins that package DNA into chromosomes, and a large number of studies have showed that several post-translational modification (PTM) sites on the histones are associated with both gene activation and silencing. Along with DNA and small non-coding RNA, histone PTMs make up epigenetic mechanisms that control gene expression patterns outside of DNA sequence mutations.…
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Christa Lese Martin, PhD, FACMG, DABMGG
Professor and Chief Scientific Officer
Director, Autism & Developmental Medicine Institute
Geisinger
presents, "Exploring the Genetics of Neurodevelopmental Psychiatric Disorders in a Health Care System" Hosted by: Dr. Tychele Turner Seminar abstract: Autism, schizophrenia, and other clinically distinct neurodevelopmental psychiatric disorders (NPD) have shared genetic etiologies, including copy number variants (CNVs) and single gene disorders. To date, rare variants that cause NPD have primarily been investigated in clinically-ascertained cohorts, therefore population-based estimates of their prevalence and penetrance are lacking. In this presentation, the prevalence, penetrance, and personal utility of NPD CNVs and…
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Evgeny Kvon, PhD
Assistant Professor
Department of Developmental & Cell Biology
University of California, Irvine
presents, "Deciphering Enhancer Function In Vivo" Hosted by: Dr. Tychele Turner Seminar abstract: Transcriptional enhancers are a predominant class of non-coding functional DNA elements that control when and where genes are expressed. We use innovative mouse genome engineering and genomics techniques to address two questions about enhancer biology: 1. How do mutations in enhancers lead to human congenital disorders? and 2. How do enhancers relay regulatory information to their target genes over long genomic distances?
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Michael Province, PhD
Professor of Genetics and Biostatistics
Director, Division of Statistical Genomics
Center for Genome Sciences and Systems Biology
Washington University School of Medicine
presents, "May you live a full life for 100 years, plus one more to repent! The Long Life Family Study" Hybrid: Connor Auditorium (FLTC) or via Zoom webinar: https://wustl-hipaa.zoom.us/j/94367220300 Hosted by: Dr. Joe Dougherty Seminar abstract: The Long Life Family Study is a multinational, multicenter, longitudinal, observational study of ~5,000 participants in ~500 pedigrees selected for high rates of extreme longevity. Fewer than 1% of the Framingham Heart Study pedigrees would qualify for LLFS. On average, this cohort shows remarkable…
Find out more »April 2022
Shannon Lauberth, PhD
Associate Professor
Department of Biochemistry and Molecular Genetics
Feinberg School of Medicine
Northwestern University
presents, "The role of noncoding RNAs in cancer: shedding light on the transcriptomic dark matter" Hosted by: Dr. Shamim Mollah HYBRID Zoom attendee webinar link:https://wustl-hipaa.zoom.us/j/94367220300 In-person: Couch Building, 6001B Seminar abstract: Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development and disease through their regulation of transcription, RNA processing, and translation. Leading the charge in the RNA revolution is a class of ncRNAs that are synthesized at active enhancers, called enhancer RNAs (eRNAs). While eRNAs have become…
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**Registration required**
CRE2-SHC Partnership presents
Race and the Future of Genomics: More Equity Or Less?
The Washington University School of Medicine's Center for the Study of Race, Ethnicity & Equity and Northwestern University’s Science in Human Culture Program host a virtual panel focusing on Race & the Future of Genomics: More Equity or Less? Register here. Panel moderator: Vence Bonham, Jr. Acting Deputy Director National Human Genome Research Institute Panelists include: Brett Maricque (McDonnell Genome Institute, Washington University in St. Louis) Alicia R. Martin (Broad Institute, Harvard Medical School, Massachusetts General Hospital) Santiago Molina (Mellon Postdoctoral Fellow,…
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Yue Zhao, PhD
Research Scientist
Department of Biomedical Informatics
The Ohio State University
VIRTUAL "Integrating gene expression profile with CRISPR pooled screen identifies essential genes with higher expression" Hosted by: Dr. Jeffrey Milbrandt
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Kin Fai Au, PhD
Associate Professor
Department of Biomedical Informatics
The Ohio State University
SPECIAL SEMINAR, HYBRID In-person: Couch Building, 6001B conference room Zoom webinar attendee link: https://wustl-hipaa.zoom.us/j/94367220300 “New sequencing technology, new data analytic methods and new insights in transcriptomics and epigenetics” Seminar abstract: Third Generation Sequencing/TGS (i.e., Oxford Nanopore Technologies/ONT and Pacific Biosciences/PacBio) can generate single-molecule long reads, ranging from a few kb to million bp. These data have been demonstrated very powerful to address many complex biomedical problems that remained unsolved by short reads. For example, the extensive applications of TGS data…
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Jeremy Reiter, MD, PhD
Professor and Chair
Department of Biochemistry and Biophysics
University of California, San Francisco
presents, "How cilia signal" Hybrid Zoom attendee webinar link: https://wustl-hipaa.zoom.us/j/94367220300 In-person: Connor Auditorium, FLTC hosted by: Drs. Susan Dutcher and Moe Mahjoub
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Jin Billy Li, PhD
Associate Professor
Department of Genetics
Stanford University
presents, “RNA Editing and Innate Immunity” Hosted by: Dr. Rob Mitra Hybrid Zoom attendee webinar link: https://wustl-hipaa.zoom.us/j/94367220300 In-person: Couch 6001B Seminar abstract: To avoid aberrant innate immunity, endogenous double-stranded RNA (dsRNA) must be edited by ADAR1, suppressing cytosolic MDA5-mediated dsRNA sensing. Mice without RNA editing by ADAR1 are embryonic lethal, but live to full life span upon MDA5 removal. In humans, ADAR1 loss-of-function and MDA5 gain-of-function mutations lead to rare autoimmune diseases. In this talk, I will discuss our recent…
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Andrew Yoo, PhD
Associate Professor
Department of Developmental Biology
Washington University School of Medicine
presents, "Modeling late-onset human neurodegeneration by neuronal reprogramming" Hosted by: Dr. Joseph Dougherty HYBRID In-person: Couch, 6001B Zoom webinar attendee link: https://wustl-hipaa.zoom.us/j/94367220300
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May 2022
23rd Annual Donald C. Shreffler Memorial Lecture
David Baker, PhD
Professor of Biochemistry & Head, Institute for Protein Design
Department of Biochemistry
University of Washington
Talk title: "Protein design using deep learning" Seminar abstract: Proteins mediate the critical processes of life and beautifully solve the challenges faced during the evolution of modern organisms. Our goal is to design a new generation of proteins that address current-day problems not faced during evolution. In contrast to traditional protein engineering efforts, which have focused on modifying naturally occurring proteins, we design new proteins from scratch to optimally solve the problem at hand. We now use two approaches. First,…
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POSTPONED to later date TBD
Panagiotis Roussos, MD, MS, PhD
Professor
Department of Genetics and Genomic Sciences
Icahn School of Medicine at Mount Sinai
presents, "Title TBD" Hosted by: Dr. Joe Dougherty
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Ami Bhatt, MD, PhD
Associate Professor
Departments of Medicine (Hematology) and Genetics
Stanford University
presents, "From precise microbial genomics to precision medicine" Talk abstract: The Bhatt lab seeks to illuminate the interplay between the microbial environment and host/clinical factors in human diseases. In this talk, Dr. Bhatt will share exciting new developments on the application of novel molecular and computational tools to study strain level dynamics of the microbiome, understand how microbial genomes change over time and predict the functional output of microbiomes. She will also speak about recent efforts to understand how microbes “talk” to one another…
Find out more »July 2022
Jian Ma, PhD
Ray and Stephanie Lane Professor of Computational Biology
School of Computer Science
Carnegie Mellon University
“MACHINE LEARNING FOR SPATIAL GENOMICS” This is a hybrid in-person and virtual event. The seminar will take place in the Eric P. Newman Education Center (EPNEC), Seminar Room B Virtual attendees can join via Zoom webinar link: https://bit.ly/3o4mMYT Passcode: b0726
Find out more »September 2022
MGI Seminar Series – CompBio V2.5 Release Seminar
"CompBio V2.5 - New Functionality, Enhanced Memory Model, and Comparative Analytics" Join Zoom webinar. Hosted by: Rich Head CompBio(version 2.5), a next-generation omics analysis platform developed at Washington University, is now in production and available to all Washington University investigators. With utilization by ~200 users/labs at Wash U and cited research application in high-impact journals such as Nature, Cell, PNAS, Cell Metabolism, Journal of the American College of Cardiology, and numerous others, we continue to receive requests for enhancements to…
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24th Annual Donald C. Shreffler Memorial Lecture
Karl Deisseroth, MD, PhD
D.H. Chen Professor of Bioengineering & of Psychiatry and Behavioral Sciences
Department of Bioengineering
Stanford University
presents, "Inner Workings of Channelrhodopsins and Brains" Hosted by: Dr. Jeffrey Milbrandt Zoom webinar attendee link: https://wustl-hipaa.zoom.us/j/94367220300 Click here to learn more about Dr. Shreffler and the lecture named for him.
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***CANCELLED*** Kate O’Connor-Giles, PhD
Provost’s Associate Professor of Brian Science
Department of Neuroscience
Carney Institute for Brain Science
Brown University
***CANCELLED***
This seminar has been cancelled.
Find out more »October 2022
Brandon Pierce, PhD
Associate Professor
Departments of Public Health Sciences & Human Genetics
University of Chicago
presents, "Genetic and environmental determinants of DNA methylation in diverse human tissue types" Hosted by: Dr. Nancy Saccone In-person only: Connor Auditorium (FLTC) Talk abstract: Tissue-specific characterization of variability in DNA methylation (DNAm) is needed to understand its role in gene regulation and its relevance to complex traits. We generated array-based DNAm profiles for ~1000 human samples from the Genotype-Tissue Expression (GTEx) project, representing 9 tissue types. This talk will highlight (1) the contribution of inherited genetic variation and tobacco…
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Emma Farley, PhD
Assistant Professor
Department of Medicine
University of California-San Diego
presents, "Affinity optimizing enhancer variants disrupt development" Hosted by: Dr. Barak Cohen In-person only: Connor Auditorium (FLTC) Talk abstract: An emerging regulatory principle governing enhancers is the use of suboptimal affinity binding sites to encode tissue-specific gene expression during development. Here we discover that affinity optimizing single-nucleotide variants can violate this principle, disrupt tissue-specific gene expression, and alter phenotypes in Ciona, mice, and humans.
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Barbara Cheifet, PhD
Senior Editor
Nature Biotechnology
Springer Nature
presents, "Publishing for impact" Hosted by: Dr. Ting Wang In-person only: Connor Auditorium (FLTC) Talk abstract: In this talk, I will share tips on the publishing process, what journals look for, and how to productively interact with editors. I will also look forward to answering any questions related to academic publishing.
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Laurence Pelletier, PhD
Principal Investigator & Cancer Cell Biologist
Lunenfeld-Tanenbaum Research Institute, Toronto
presents, "Protein interaction profiling of centrosomes in normal and disease states" Talk abstract: The centrosome is the major microtubule-organizing center (MTOC) in animal cells. Centrosomes control a plethora of cellular processes including the organization of the interphase microtubule network, the assembly of the mitotic spindle and the formation of cilia/flagella. Mitotic cell division relies on the formation of a robust bipolar spindle, which mediates the accurate segregation of genetic material to daughter cells. In mitosis, two centrosomes need to be…
Find out more »November 2022
Proteomics Symposium (Day1)
REGISTRATION REQUIRED. The McDonnell Genome Institute, Advances in High-Throughput Proteomics Symposium brings together investigators utilizing proteomics technologies to discuss both real-world research applications and technological advancements. The format is designed to foster idea sharing across our region in the rapidly evolving field of -omics research. The program includes two days of interactive discussion sessions that will be both in-person and available via Zoom. Day One will be hosted by the Genome Technology Access Center (GTAC@MGI) and will be devoted to…
Find out more »Proteomics Symposium (Day2)
REGISTRATION REQUIRED. The McDonnell Genome Institute, Advances in High-Throughput Proteomics Symposium brings together investigators utilizing proteomics technologies to discuss both real-world research applications and technological advancements. The format is designed to foster idea sharing across our region in the rapidly evolving field of -omics research. The program includes two days of interactive discussion sessions that will be both in-person and available via Zoom. Day Two will be the MTAC Inaugural Symposium sponsored by Mass Spectrometry Technology Access Center (MTAC@MGI) and…
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Kun Zhang, PhD
Professor
Department of Bioengineering
University of California, San Diego
presents, "A multi-omics cell atlas for human healthy and disease kidney" Hosted by: Dr. Shamim Mollah In-person only: Connor Auditorium (FLTC) Talk abstract: Detailed characterization of the cell types comprising the highly complex human organs is essential to understanding their functions. Such tasks require highly scalable experimental approaches to examine multiple aspects of the molecular state of individual cells, registering cells to 3D coordinates, as well as the computational integration to produce unified cell state annotations and interpretation with biological…
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Xiaoxia Cui, PhD
Assistant Professor
The Genome Engineering & Stem Cell Center
McDonnell Genome Institute
Washington University School of Medicine
presents, "Cell and Animal models in the Era of CRISPR" Hosted by: McDonnell Genome Institute In-person only: Connor Auditorium (FLTC)
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Samantha Morris, PhD
Associate Professor
Departments of Genetics and Developmental Biology
Washington University School of Medicine
presents, "What are my cells? A journey into cell identity and new genomic technologies" Hosted by: Dr. Joe Dougherty In-person only: Connor Auditorium (FLTC) Talk abstract: A mechanistic understanding of how cell identity is established and maintained is fundamental to the precise engineering of cell fate. Here, I will present new genomic technologies developed by my lab to permit single-cell lineage tracing throughout reprogramming, accompanied by recording of TF-binding and chromatin accessibility profiling. Integrating this information using our unique computational tools for interrogating gene regulatory networks…
Find out more »December 2022
Hui Shen, PhD
Associate Professor
Department of Epigenetics
Van Andel Institute
presents, 'Cancer Epigenetics’: what is in a name? Talk abstract: Cancer epigenetic studies to date have largely focused on the impact of heritable non-genetic molecular alternations on gene function – inactivating tumor suppressor genes or activating oncogenes, much akin to genetic mutations. However, despite the widely used modern operative definition of the word ‘epigenetics’ – as a description of various modifications to the chromatin, the concept of ‘epigenetics’ was originally used to describe cellular characteristics. Using cancers arising from the female…
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Jeffrey Miner, PhD
E & J Slatopolsky Professor of Medicine in Nephrology
Division of Nephrology
Department of Medicine
Washington University School of Medicine
presents, "Genetic manipulation of the kidney’s filtration barrier: insights into Alport syndrome" Hosted by: Dr. Tychele Turner In-person only: Connor Auditorium (FLTC)
Find out more »January 2023
Erik Musiek, MD, PhD
Charlotte & Paul Hagemann Professor
Department of Neurology
Washington University School of Medicine
presents, "Regulation of glial cell gene expression and function by the circadian clock" Hosted by: Dr. Tristan Li In-person only: Connor Auditorium (FLTC)
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Francesca Luca, PhD
Professor
Center for Molecular Medicine and Genetics
Wayne State University School of Medicine
presents, "Single cell analysis of Gene-Environment interactions: not your average eQTL" Hosted by: Dr. Barak Cohen In-person only: Connor Auditorium (FLTC) Talk abstract: In the past ten years we have been studying genetic and environmental factors that contribute to asthma severity in children living in the metropolitan Detroit area. We have performed bulk and single cell RNA-sequency and uncovered psychosocial and genetic factors associated with gene regulation in children with asthma. I will present our findings on the dynamic genetic…
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Precision Medicine Pathway Keynote
Karen Miga, PhD
Assistant Professor
Department of Biomolecular Engineering
University of California, Santa Cruz
presents, "Expanding studies of global genomic diversity with complete, telomere-to-telomere (T2T) assembly of diploid genomes" Hosted by: Dr. Ting Wang In-person only: Connor Auditorium (FLTC) Talk abstract: The Telomere-to-Telomere (T2T) Consortium has finished the first truly complete human genome, representing gapless assemblies for all 22 autosomes plus Chromosomes X and Y, corrects numerous errors, and introduces nearly 200 million bp of novel sequence. Here I will discuss new methods to automate T2T diploid chromosome assembly and quality assessment, and the…
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Special Genetics Seminar
Michael Haney, PhD
Postdoctoral Fellow
Wyss-Coray Lab, Department of Neuroscience
Stanford University
presents, "Neuroimmune Interactions in Alzheimer’s Disease and Aging" Hosted by: Drs. Jeffery Milbrandt and Jin-Moo Lee In-person only: Moore Auditorium (North Building) Talk abstract: Neuroinflammation driven by reactive glia and immune cell infiltration is a hallmark of many neurodegenerative diseases and brain aging. However, there remain gaps in our knowledge on the causal mechanisms by which reactive glia and peripheral immune cells modulate neuronal function in aging and disease. Recently developed in vivo and iPSC based CRISPR KO screening approaches reveal…
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WEBINAR
Marian Walhout, PhD
Professor & Chair
Department of Systems Biology
University of Massachusetts Chan Medical School
presents, "Worms, bugs & drugs" Hosted by: Dr. Tychele Turner FULLY VIRTUAL Zoom webinar attendee link: https://wustl-hipaa.zoom.us/j/94367220300
Find out more »February 2023
Nenad Sestan, MD, PhD
Harvey and Kate Cushing Professor of Neuroscience
Professor of Comparative Medicine, Genetics, & Psychiatry
Department of Neuroscience
Yale University School of Medicine
presents, "What Makes Us Human? Development and Evolution of Prefrontal Circuits Underlying Cognitive Control" Hosted by: Dr. Peter Jin In-person only: Connor Auditorium (FLTC) Talk abstract: In my presentation, I will describe some of our recent efforts to better understand the molecular and cellular basis of how neural circuits form within the developing cerebral cortex, the outside part of the mammalian brain that processes our senses, commands motor activity, and helps us perform higher-order cognitive functions like language. I will…
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Susan Strome, PhD
Distinguished Professor of Molecular, Cell, & Developmental Biology
Department of Molecular, Cell, & Developmental Biology
University of California-Santa Cruz
presents, "Inherited chromatin states shape transcription patterns in offspring and grandoffspring" Talk abstract: The role that chromatin states serve in transmitting gene expression information across generations via sperm and oocytes is not well understood. We utilized a model in which C. elegans sperm and oocyte alleles were inherited in different states of the repressive mark H3K27me3. This resulted in the alleles achieving different transcriptional states within the nuclei of offspring. Using this model, we showed that sperm alleles inherited without H3K27me3 were sensitive to up-regulation in offspring…
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Kristen Kroll, PhD
Professor
Department of Developmental Biology
Washington University School of Medicine
presents, "Epigenetic regulation of human cortical development and its disruption to cause neurodevelopmental disorders" Talk abstract: Work in my laboratory focuses on modeling gene regulatory networks that control various aspects of human brain development. We are interested in identifying novel transcriptional and epigenetic regulators of these networks, defining mechanisms by which they control brain development, and studying how pathogenic mutations in genes encoding these regulators contribute to neurodevelopmental disorders. Hosted by: Dr. Tristan Li In-person only: Connor Auditorium (FLTC)
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MGI Seminar Series
Willie Buchser, PhD
Associate Professor
Department of Genetics
McDonnell Genome Institute
Washington University School of Medicine
presents, "Deep Cellular Phenotyping, the newest tools for Omics or Screening" In-person only: Connor Auditorium (FLTC) Talk abstract: Cell based deep phenotyping allows immediate study of a patient’s exact variant without generating a mouse, fly, or worm model (which may not even have the orthologous gene let alone the exact mutant). Instead of lengthy assay development, confocal imaging can uncover subtle functional changes to cellular morphology and organelles. These phenotypes are further enhanced by multi-feature machine learning approaches that can…
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Xuehua Zhong, PhD
Professor
Department of Biology
Washington University
presents, "Epigenetic regulation and environmental adaptation" Talk abstract: The Zhong laboratory is interested in how cellular machines sense intrinsic and extrinsic cues and alter chromatin landscapes to generate adaptive responses. They focus on epigenetic regulation by exploring how chromatin dynamics is established, maintained, erased, and inherited over time, and how altered chromatin modifications lead to improved plant traits and environmental adaptation. They combine functional genomics and high-throughput proteomics and genomics techniques together with genetic and biochemical tools to understand the function…
Find out more »March 2023
Marius Wernig, MD, PhD
Professor of Pathology & Co-Director
Institute for Stem Cell Biology and Regenerative Medicine
Stanford University
presents, "Cellular reprogramming to study neuronal lineage specification and develop cell therapies for the brain" Talk title: I will talk about neuronal cell specification centered around transcription factor regulation and applications of microglia replacement therapies. Hosted by: Dr. Joe Dougherty In-person only: Connor Auditorium (FLTC)
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Chad Pearson, PhD
Associate Professor
Department of Cell & Developmental Biology
University of Colorado Anschutz Medical Campus
presents, "Negative impacts of chromosome 21 gene dosage on primary cilia formation and signaling" Talk abstract: Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21. Our work reveals that elevated Pericentrin from trisomy 21 disrupts multiple early steps of ciliogenesis and creates persistent trafficking defects in ciliated cells and in a mouse model of Down syndrome. Hosted by: Dr. Susan Dutcher In-person only: …
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Ann Morning, PhD
Professor
Department of Sociology
New York University
presents, "Genetics in the Racial Imagination" Hosted by: Dr. Brett Maricque In-person only: Connor Auditorium (FLTC) Talk abstract: How does genetics figure in everyday Americans’ beliefs about racial difference? Drawing on interviews with college students, textbook lessons, and public controversies over racial identity, I trace the ways in which many Americans link race to biological variation. And I briefly take up the counterpoint question—how does race figure in genetics?—by concluding with a discussion of the National Academies of Sciences, Engineering,…
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Student-invited speaker
Melissa Boneta Davis, PhD
Inaugural Georgia Research Alliance Distinguished Investigator
Institute of Translational Genomic Medicine
Morehouse School of Medicine
presents, "Role of African Ancestry in genomic and proteomic changes in breast cancer disparities" Hosted by: Alla Karpova and Genetics trainees & postdocs In-person only: Connor Auditorium (FLTC)
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Bruce Gelb, MD
Professor & Dean for Child Health Research
Gogel Family Chair & Director of The Mindich Child Health & Development Institute
Director of the Center for Molecular Cardiology
Departments of Pediatrics and Genetics & Genomic Sciences
Icahn School of Medicine @ Mount Sinai
presents, "The RASopathies: Too much, too little and getting to just right" Talk abstract: Noonan syndrome and the related disorders, now called the RASopathies, are phenotypically related traits arising from perturbations, largely engendering gain of function, in the RAS/mitogen-activated protein kinase signal transduction pathway. In this lecture, insights gained from phenotype-first and genotype-first studies of the RAsopathies will be provided as well as those from cell and animal model research, informing the development of mechanistic therapies for these genetic traits.…
Find out more »April 2023
Karen Oegema, PhD
Professor
Department of Cellular & Molecular Medicine
University of California, San Diego School of Medicine
presents, "Time is (not) on your side: mitotic control of G1 progression" Hosted by: Dr. Susan Dutcher In-person only: Connor Auditorium (FLTC)
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Jennifer Wang, PhD
Assistant Professor
Department of Biology
Washington University in St. Louis
presents, "Fitting the pieces together: how cells make centrosomes and cilia" Talk abstract: The Wang lab studies how the architecture of organelles is created, and how architecture relates to cellular function and physiology. We are particularly interested in centrosomes and cilia, conserved organelles involved in cell division, signaling, and motility. I will discuss our work on a unique architectural element of centrosomes, the triplet microtubules, as well as our work on centrosome and cilia architecture in olfactory sensory neurons. Hosted…
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Ali Mortazavi, PhD
Professor
Department of Developmental and Cell Biology
University of California, Irvine
presents, "Transcript structure diversity and postnatal transcriptional regulation in ENCODE4" Hosted by: Dr. Heather Lawson In-person only: Connor Auditorium (FLTC)
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Ellen Hoffman, MD, PhD
Associate Professor
Yale Child Study Center & Yale Neurogenetics Program
Yale University School of Medicine
presents, "Functional analysis of autism risk genes in zebrafish" Hosted by: Dr. Joe Dougherty In-person only: Connor Auditorium (FLTC)
Find out more »May 2023
Jesse Engreitz, PhD
Assistant Professor
Department of Genetics
Stanford University
presents, "Mapping the regulatory wiring of the genome to connect disease variants to functions" Talk abstract: I will present two new stories from the lab. First, I will describe unpublished work regardin how cohesin tunes 3D enhancer-promoter communication. Second, I will present work to map genes and pathways for coronary artery disease using large-scale Perturb-seq. Hosted by: Dr. Heather Lawson In-person only: Connor Auditorium (FLTC)
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Lacra Bintu, PhD
Assistant Professor of Bioengineering
Department of Bioengineering
Stanford University
presents, "The sequence determinants of human transcriptional activators and repressors: high-throughput discovery and systematic perturbations" Hosted by: Dr. Barak Cohen In-person only: Connor Auditorium (FLTC) Talk abstract: Human transcription factors (TFs) contain binding domains that allow them to recognize specific DNA sequences and effector domains that interact with transcriptional machinery or other cofactors to activate or repress transcription. By performing high-throughput pooled measurements testing ~110,000 candidate sequences that are consecutive fragments from human transcription factors and chromatin regulators, we were able to…
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Ben Major, PhD
Alan A. and Edith L. Wolff Professor of Cell Biology and Physiology
Departments of Cell Biology & Physiology and Otolaryngology
Washington University School of Medicine
presents, "Integrative Proximity Proteomics Reveals Mechanisms and Therapeutic Opportunities for the KEAP1/NRF2 Signaling Pathway" Hosted by: Dr. Tychele Turner In-person only: Connor Auditorium (FLTC)
Find out more »June 2023
Student-invited speaker
Stephen Johnson Memorial Lecture
Jessica Tollkuhn, PhD
Associate Professor
Cold Spring Harbor Laboratory
presents, "Hormonal regulation of gene expression defines sex-variable biology" Talk abstract: My lab studies how nuclear hormone receptors modulate gene expression in the brain at single-cell resolution, and how this affects development of and activity within circuits that mediate specific behaviors. We anticipate that the hormone-regulated genes we have identified will contribute to established sex differences in the incidence and etiology of neurological and psychiatric disorders. Hosted by: Simona Sarafinovska, Din Selmanovic, and Genetics trainees & postdocs In-person only: Connor…
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25th Donald C. Shreffler Memorial Lecture
Aaron Gitler, PhD
Professor
Department of Genetics
Stanford University
"Expanding mechanisms and therapeutic targets for neurodegenerative disease" Hosted by: Dr. Jeffrey Milbrandt Location: Connor Auditorium (FLTC) Talk abstract: Human neurodegenerative diseases are associated with the accumulation of protein aggregates. I will describe recent efforts using genetic modifier screens in model systems and human genetics to define the mechanisms by which misfolded human disease proteins contribute to neurodegeneration. These studies have revealed new targets for therapeutic intervention.
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Genetics Special Seminar
Itay Tirosh, PhD
The Dr. Celia Zwillenberg-Fridman & Dr. Lutz Zwillenberg
Career Development Chair
Department of Molecular Cell Biology
Weizmann Institute of Science
Pan-cancer analysis of intra-tumor heterogeneity Hosted by: Dr. Sid Puram Location: Connor Auditorium (FLTC) Talk abstract: Over the last few years we have been investigating intra-tumor heterogeneity by applying single cell RNA-seq to various cancer types. I will present our results in specific contexts and our integrative pan-cancer analysis, highlighting recurrent patterns of heterogeneity.
Find out more »September 2023
Stephen Johnson Memorial Lecture
Student-invited speaker
Marija Kundakovic, PhD
Associate Professor
Department of Biological Sciences
Fordham University
presents, "Epigenomic (re)programming of the brain and behavior by ovarian hormones" Hosted by: Sneha Chaturvedi & Genetics' trainees & postdocs In-person only: Connor Auditorium (FLTC)
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Mike Gandal, MD, PhD
Hetznecker Associate Professor of Psychiatry
Department of Psychiatry
Perelman School of Medicine
University of Pennsylvania
presents, "Isoform regulation in the developing human brain informs mechanisms of neuropsychiatric disorders" Hosted by: Dr. Joe Dougherty In-person only: Connor Auditorium (FLTC) Talk abstract: Large-scale genetic studies have now identified hundreds of common and rare variants associated with neurodevelopmental and psychiatric disorders. However, interpretation of the biological functional impact and pathogenicity of these variants remains a critical obstacle hindering clinical translation. To address this challenge, we have developed a large-scale functional genomic atlas of human brain development, integrating genotype…
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MGI Seminar Series
Rich Head, MS
Professor, Department of Genetics
Director, Genome Technology Access Center @ McDonnell Genome Institute (GTAC@MGI)
Washington University School of Medicine and
Robert Fulton, MS
Assistant Professor, Department of Genetics
McDonnell Genome Institute
Washington University School of Medicine
presents, “Spatial: The New Frontier - Spatial and Single Cell Capabilities at the McDonnell Genome Institute” In-person only: Connor Auditorium (FLTC)
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Precision Medicine Pathway Keynote Address
Wendy Chung, MD, PhD
Chief, Department of Pediatrics
Kennedy Family Professor of Pediatrics in Medicine
Department of Pediatrics
Harvard Medical School and Boston Children’s Hospital
presents, "Supporting Equity in Precision Pediatrics" Hosted by: Dr. Tim Schedl and Julie Choi (Milbrandt & Jin labs) In-person only: Connor Auditorium (FLTC) Talk abstract: Sequencing-based genomic NBS can significantly expand NBS to numerous rare genetic diseases with a single common platform and provide synergies with traditional newborn screening and across conditions to decrease the cost/condition for screening and de-risk the investment across diseases/companies providing/developing treatments for rare genetic diseases. Pilot studies of genomic NBS will improve timely access to…
Find out more »October 2023
Daniel Lew, PhD
Professor
Department of Biology
MIT
presents, "Cell Polarity and Chemical Gradient tracking in Yeast" Hosted by: Dr. Susan Dutcher In-person only: Connor Auditorium (FLTC) Talk abstract: How cells orient polarity in response to chemical gradients is a fundamental but poorly understood process. We use the pheromone-tracking ability of mating yeast as a model to dissect basic principles.
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Yang Li, PhD
Assistant Professor
Departments of Genetics & Neuroscience
Washington University
presents, "Single-Cell Epigenomic Analysis of Mammalian Brains and Neurological Disorders" Hosted by: Dr. Tristan Li In-person only: Connor Auditorium (FLTC)
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Zhana Duren, PhD
Assistant Professor
Department of Genetics & Biochemistry
Clemson University
presents, "Gene regulatory network analysis from single cell multi-omics data" Hosted by: Dr. Tychele Turner In-person only: Connor Auditorium (FLTC)
Find out more »November 2023
Jeffrey Milbrandt, MD, PhD
James S. McDonnell Professor of Genetics and Chair
Department of Genetics
Executive Director
McDonnell Genome Institute
Washington University School of Medicine
presents, "Neurometabolic Underpinnings of Peripheral Neurodegenerative Disorders" Hosted by: Dr. Joe Dougherty In-person only: Connor Auditorium (FLTC)
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Jessica Feldman, PhD
Associate Professor
Department of Biology
Stanford University
presents, "Building patterns in cells during development" Hosted by: Dr. Susan Dutcher In-person only: Connor Auditorium (FLTC)
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Kristopher Kahle, MD, PhD
Associate Professor & Director, Pediatric Neurosurgery
Department of Neurosurgery
Harvard Medical School and Massachusetts General Hospital
presents, "Genomics of developmental brain anomalies" Hosted by: Dr. Peter Jin In-person only: Connor Auditorium (FLTC)
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Don Fox, PhD
Associate Professor
Department of Pharmacology & Cancer Biology
Duke University
presents, "Super-sized cells and not-so-silent mutations in organ development" Hosted by: Dr. Susan Dutcher In-person only: Connor Auditorium (FLTC)
Find out more »December 2023
Shaun Mahony, PhD
Associate Professor
Department of Biochemistry & Biology
Eberly College of Science
Penn State University
presents, "Understanding the sequence and chromatin predeterminants of induced transcription factor binding with neural networks" Hosted by: Dr. Shamim Mollah In-person only: Connor Auditorium (FLTC)
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Mia Levine, PhD
Associate Professor
Department of Biology
University of Pennsylvania
presents, "Intra-genomic conflict and the evolution of genome integrity" Hosted by: Dr. Ting Wang In-person only: Connor Auditorium (FLTC)
Find out more »January 2024
Harrison Gabel, PhD
Associate Professor
Department of Neuroscience
Washington University School of Medicine
presents, "Dissecting epigenetic mechanisms in nervous system development and disease" Hosted by: Dr. Tristan Li In-person only: Connor Auditorium (FLTC)
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Dagmar Wachten, PhD
Principal Investigator
Department of Biophysical Imaging & Molecular Physiology
Institute of Innate Immunity
University of Bonn
presents, "Shedding light on ciliary signaling and function" Hosted by: Dr. Susan Dutcher In-person only: Connor Auditorium (FLTC)
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Alexis Battle, PhD
Associate Professor
Department of Biomedical Engineering
Johns Hopkins University
presents, "Genetics of gene expression across cell-type, time, and space" Hosted by: Dr. Barak Cohen In-person only: Connor Auditorium (FLTC)
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Tony Tsai, MD, PhD
Assistant Professor
Department of Developmental Biology
Washington University School of Medicine
presents, "How to make precise tissue patterns with noisy instructions?" Hosted by: Dr. Peter Jin In-person only: Connor Auditorium (FLTC)
Find out more »February 2024
Danny Miller, MD, PhD
Assistant Professor
Departments of Pediatrics and Laboratory Medicine & Pathology
University of Washington
presents, "Streamlining research and clinical genetic testing: the promise of long-read sequencing" Hosted by: Dr. Peter Jin In-person only: Connor Auditorium (FLTC)
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Lea Starita, PhD
Research Assistant Professor
Department of Genome Sciences
University of Washington
presents, "Understanding genetic variation at scale" Hosted by: Dr. Heather Lawson In-person only: Connor Auditorium (FLTC)
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Geraldine Seydoux, PhD
Huntington Sheldon Professor in Medical Discovery
Department of Molecular Biology and Genetics
Johns Hopkins University School of Medicine
presents, "Assembly and function of RNA granules in the C. elegans germline" Hosted by: Dr. Tim Schedl In-person only: Connor Auditorium (FLTC)
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Daniel De Carvalho, PhD
Helen M. Cooke Professor of Cancer Epigenetics
Princess Margaret Cancer Centre
Professor
Molecular Neurobiology Laboratory
University of Toronto
presents, "Ultra-Sensitive Tumor Detection and Classification using Methylome Analysis of Plasma cfDNA" Hosted by: Dr. Ting Wang In-person only: Connor Auditorium (FLTC)
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Nicola Allen, PhD
Associate Professor
Molecular Neurobiology Laboratory
Salk Institute for Biological Studies
presents, "Astrocyte-neuron interaction in health and disease" Hosted by: Dr. Guoyan Zhao In-person only: Connor Auditorium (FLTC)
Find out more »March 2024
Nadav Ahituv, PhD
Professor
Department of Bioengineering and Therapeutic Sciences
University of California, San Francisco
presents, "Functional characterization and therapeutic targeting of gene regulatory elements" Hosted by: Dr. Barak Cohen In-person only: Connor Auditorium (FLTC)
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Michael Schatz, PhD
Bloomberg Distinguished Professor
Department of Computer Science & Quantitative Biology
Johns Hopkins University
presents, "Computing at scale with the NHGRI AnVIL" Hosted by: Dr. Tychele Turner In-person only: Connor Auditorium (FLTC)
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Anshul Kundaje, PhD
Associate Professor
Department of Genetics
Stanford University
presents, "Deep learning the cis-regulatory code and single base and single cell resolution" Hosted by: Dr. Heather Lawson In-person only: Connor Auditorium (FLTC)
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Siavash Kurdistani, MD
Professor and Chair
Department of Biological Chemistry
University of California, Los Angeles
presents, "Histones and Copper: A common thread from eukaryogenesis to human disease" Hosted by: Dr. Gabor Egervari In-person only: Connor Auditorium (FLTC)
Find out more »April 2024
Xian Piao, MD, PhD
Benioff Professor in Children’s Health
Director, the Newborn Brain Research Institute
Vice Chief of Academics, Division of Neonatology
presents, "G protein-coupled receptor-depending brain development and malformation" Hosted by: Dr. Tristan Li In-person only: Connor Auditorium (FLTC)
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Mike Love, PhD
Associate Professor
Departments of Genetics & Biostatistics
University of North Carolina, Chapel Hill
presents, "Assaying effects of GWAS variants in organs with in vivo massively parallel reporter assay (MPRA)" Hosted by: Dr. Heather Lawson In-person only: Connor Auditorium (FLTC)
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Mustafa Aydogan, DPhil
Assistant Professional Researcher
Department of Biochemistry & Biophysics
University of California, San Francisco
presents, "Autonomous clocks in cytoplasmic organization and division" Hosted by: Dr. Susan Dutcher In-person only: Connor Auditorium (FLTC)
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Fritz Sedlazeck, PhD
Associate Professor
Human Genome Sequencing Center
Baylor College of Medicine
presents, "Genomic Structural Variations and beyond 1" Hosted by: Dr. Peter Jin In-person only: Connor Auditorium (FLTC)
Find out more »May 2024
Bal Khakh, PhD
Professor
Departments of Physiology & Neurobiology
University of California, Los Angeles
presents, "Unmasking astrocyte roles in neural circuits and disease" Hosted by: Dr. Joe Dougherty In-person only: Connor Auditorium (FLTC)
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Student-invited speaker, Stephen Johnson Memorial Lecture
Jesse Gillis, PhD
James B. Bassingthwaighte Chair in Integrative Physiology
Department of Physiology
University of Toronto
presents, "High-throughput inference to understand cell programs in evolution and development" Hosted by: Simona Sarafinovska, Sneha Chaturvedi, & Genetics' trainees & postdocs In-person only: Connor Auditorium (FLTC)
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